The W.E.B. Du Bois Memorial Centre for Pan-African Culture is a historic landmark in Accra dedicated to the life and work of Dr. William Edward Burghardt Du Bois (1868–1963), an African-American scholar, civil rights activist, sociologist, historian, and Pan-Africanist.

Dr. Du Bois was invited to Ghana in 1961 by President Kwame Nkrumah to work on the Encyclopaedia Africana, a monumental project aimed at documenting African history, culture, and achievements from a Pan-African perspective. He spent his final two years in Ghana, living in the residence that now houses the centre.

The Memorial Centre was officially inaugurated in 1985 by the Government of Ghana to honor Du Bois's contributions to African unity and intellectual thought. Today, it serves as:

• A research library with rare collections of books, manuscripts, and personal items belonging to Du Bois.
• A mausoleum where Du Bois and his wife, Shirley Graham Du Bois, are buried.
• A museum showcasing Pan-African history, photographs, and memorabilia.
• A cultural hub for lectures, exhibitions, and conferences on African heritage and unity.